Non-Destructive Biomedical and Pharmaceutical Research Centre, Universiti Teknologi MARA, 42300 Puncak Alam, Selangor, Malaysia.
Pharm Res. 2013 Jan;30(1):90-103. doi: 10.1007/s11095-012-0852-z. Epub 2012 Aug 14.
To investigate mechanism of microwave enhancing drug permeation transdermally through its action on skin.
Hydrophilic pectin-sulphanilamide films, with or without oleic acid (OA), were subjected to drug release and skin permeation studies. The skins were untreated or microwave-treated, and characterized by infrared spectroscopy, Raman spectroscopy, thermal, electron microscopy and histology techniques.
Skin treatment by microwave at 2450 MHz for 5 min promoted drug permeation from OA-free film without incurring skin damage. Skin treatment by microwave followed by film loaded with drug and OA resulted in permeation of all drug molecules that were released from film. Microwave exerted spacing of lipid architecture of stratum corneum into structureless domains which was unattainable by OA. It allowed OA to permeate stratum corneum and accumulate in dermis at a greater ease, and synergistically inducing lipid/keratin fluidization at hydrophobic C-H and hydrophilic O-H, N-H, C-O, C=O, C-N regimes of skin, and promoting drug permeation.
The microwave technology is evidently feasible for use in promotion of drug permeation across the skin barrier. It represents a new approach in transdermal drug delivery.
研究微波通过对皮肤的作用增强药物经皮渗透的机制。
亲水果胶-磺胺嘧啶薄膜，有或没有油酸（OA），进行药物释放和皮肤渗透研究。皮肤未经处理或经微波处理，并通过红外光谱、拉曼光谱、热、电子显微镜和组织学技术进行表征。
2450 MHz 微波处理 5 分钟可促进 OA 无膜中药物的渗透，而不会造成皮肤损伤。微波处理后再加载载药和 OA 的薄膜，可使从薄膜中释放的所有药物分子都渗透。微波使角质层的脂质结构间隔成无定形结构，这是 OA 无法实现的。它使 OA 更容易渗透角质层并在真皮中积累，协同诱导角质层和角蛋白在疏水性 C-H 和亲水性 O-H、N-H、C-O、C=O、C-N 皮肤区的流体化，并促进药物渗透。
微波技术显然可用于促进药物穿过皮肤屏障的渗透。它代表了经皮给药的一种新方法。
