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物理技术如何改善治疗药物的经皮渗透：综述。

How physical techniques improve the transdermal permeation of therapeutics: A review.

机构信息

Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.

Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.

出版信息

Medicine (Baltimore). 2022 Jul 1;101(26):e29314. doi: 10.1097/MD.0000000000029314.

DOI:10.1097/MD.0000000000029314
PMID:35777055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9239599/
Abstract

BACKGROUND

Transdermal delivery is very important in pharmaceutics. However, the barrier function of the stratum corneum hinders drugs absorption. How to improve transdermal delivery efficiency is a hot topic. The key advantages of physical technologies are their wide application for the delivery of previously nonappropriate transdermal drugs, such as proteins, peptides, and hydrophilic drugs. Based on the improved permeation of drugs delivered via multiple physical techniques, many more diseases may be treated, and transdermal vaccinations become possible. However, their wider application depends on the related convenient and portable devices. Combined products comprising medicine and devices represent future commercial directions of artificial intelligence and 3D printing.

METHODS

A comprehensive search about transdermal delivery assisted by physical techniques has been carried out on Web of Science, EMBASE database, PubMed, Wanfang Database, China National Knowledge Infrastructure, and Cochrane Library. The search identified and retrieved the study describing multiple physical technologies to promote transdermal penetration.

RESULTS

Physical technologies, including microneedles, lasers, iontophoresis, sonophoresis, electroporation, magnetophoresis, and microwaves, are summarized and compared. The characteristics, mechanism, advantages and disadvantages of physical techniques are clarified. The individual or combined applicable examples of physical techniques to improve transdermal delivery are summarized.

CONCLUSION

This review will provide more useful guidance for efficient transdermal delivery. More therapeutic agents by transdermal routes become possible with the assistance of various physical techniques.

摘要

背景

经皮给药在药剂学中非常重要。然而，角质层的屏障功能阻碍了药物的吸收。如何提高经皮给药效率是一个热门话题。物理技术的主要优势在于它们广泛应用于以前不适合经皮给药的药物，如蛋白质、肽和亲水药物的传递。基于多种物理技术所带来的药物渗透能力的提高，更多的疾病可能得到治疗，经皮疫苗接种成为可能。然而，它们的更广泛应用取决于相关的便捷和便携式设备。包含药物和设备的联合产品代表了人工智能和 3D 打印的未来商业方向。

方法

我们在 Web of Science、EMBASE 数据库、PubMed、万方数据库、中国知网和 Cochrane 图书馆上全面检索了物理技术辅助经皮给药的相关研究。检索确定并检索了描述多种物理技术以促进经皮渗透的研究。

结果

总结并比较了物理技术，包括微针、激光、离子电渗、声透、电穿孔、磁泳和微波。阐明了物理技术的特点、机制、优缺点。总结了物理技术单独或联合应用于提高经皮传递的实例。

结论

本综述将为高效经皮给药提供更有用的指导。在各种物理技术的辅助下，更多的治疗药物可以通过经皮途径给药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bc/9239599/36630c507572/medi-101-e29314-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bc/9239599/36630c507572/medi-101-e29314-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bc/9239599/ea0538b9a139/medi-101-e29314-g006.jpg
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