Patel Peysh, Sandoe Jonathan, Baig Wazir
Leeds General Infirmary, Leeds, UK.
BMJ Case Rep. 2012 Aug 13;2012:bcr0120125668. doi: 10.1136/bcr.01.2012.5668.
Teicoplanin is used in a wide range of clinical settings, owing to its wide antiGram positive bacterial activity. Although it is generally well tolerated, adverse reactions such as fever and rash are well recognised. Haematological sequelae have been rarely reported. This case report describes the development of teicoplanin-induced leucopenia in a patient with infective endocarditis. A short course of lenograstim, a recombinant granulocyte colony-stimulating factor (G-CSF) reverted biochemical abnormalities. To the authors' best knowledge, this is the first documented example of implementation of G-CSF in such a clinical setting.
替考拉宁因其广泛的抗革兰氏阳性菌活性而被用于多种临床环境。虽然它通常耐受性良好，但发热和皮疹等不良反应已广为人知。血液学后遗症鲜有报道。本病例报告描述了一名感染性心内膜炎患者发生替考拉宁诱导的白细胞减少症。短疗程使用重组粒细胞集落刺激因子（G-CSF）来那度胺可逆转生化异常。据作者所知，这是在这种临床环境中使用G-CSF的首个有记录的实例。
