用替考拉宁替代后，万古霉素诱导的中性粒细胞减少症得以缓解。

Vancomycin-induced neutropenia resolves after substitution with teicoplanin.

作者信息

Sanche S E, Dust W N, Shevchuk Y M

机构信息

Division of Infectious Diseases, Royal University Hospital, Saskatoon, SK, Canada.

出版信息

Clin Infect Dis. 2000 Sep;31(3):824-5. doi: 10.1086/314028.

DOI:10.1086/314028

PMID:11017842

Abstract

Neutropenia is an uncommon adverse effect associated with prolonged vancomycin therapy. Neutrophil counts normally recover after discontinuation of vancomycin in this situation, but treatment options are needed for those patients who require ongoing antibiotic therapy. We describe a case of vancomycin-induced neutropenia in which the neutropenia resolved after vancomycin was replaced by the structurally related compound teicoplanin.

摘要

中性粒细胞减少是与万古霉素长期治疗相关的一种罕见不良反应。在这种情况下，停用万古霉素后中性粒细胞计数通常会恢复，但对于那些需要持续抗生素治疗的患者，仍需要治疗方案。我们描述了一例万古霉素诱导的中性粒细胞减少病例，在万古霉素被结构相关化合物替考拉宁替代后，中性粒细胞减少得到缓解。