Borgbjerg B M, Hovgaard D, Laursen J B, Aldershvile J
Medical Department B, Rigshospitalet, Blegdamsvej 9, Copenhagen, Denmark.
Heart. 1998 Jan;79(1):93-5. doi: 10.1136/hrt.79.1.93.
A well known complication in the treatment of infectious endocarditis is development of neutropenia caused by treatment with antibiotics in high concentrations over long periods. Neutropenia often necessitates discontinuation of antibiotic treatment. Three patients with infectious endocarditis who developed neutropenia are reported. The patients were treated with granulocyte colony stimulating factor (G-CSF), a haematopoietic growth factor that stimulates neutrophils. G-CSF induced an immediate increase in white blood cell count, primarily neutrophils. G-CSF may be effective in ameliorating neutropenia in patients who receive antibiotics for treatment of infectious endocarditis.
感染性心内膜炎治疗中一种众所周知的并发症是长期使用高浓度抗生素治疗导致的中性粒细胞减少。中性粒细胞减少常常需要停用抗生素治疗。本文报告了3例发生中性粒细胞减少的感染性心内膜炎患者。这些患者接受了粒细胞集落刺激因子（G-CSF）治疗，G-CSF是一种刺激中性粒细胞的造血生长因子。G-CSF使白细胞计数立即增加，主要是中性粒细胞。G-CSF可能对改善接受抗生素治疗感染性心内膜炎患者的中性粒细胞减少有效。
