Palha Joana A, Santos Nadine C, Marques Fernanda, Sousa João, Bessa João, Miguelote Rui, Sousa Nuno, Belmonte-de-Abreu Paulo
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho Braga, Portugal.
Front Cell Neurosci. 2012 Aug 8;6:31. doi: 10.3389/fncel.2012.00031. eCollection 2012.
Schizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia.
精神分裂症是一种神经发育障碍，其中基因与环境的相互作用促成了疾病的发生和发展。精神分裂症患者最一致的病理特征是脑室扩大。然而，迄今为止，尚无研究将这一发现与脉络丛（CP）功能障碍联系起来，脉络丛是位于脑室内的上皮细胞单层，负责产生大部分脑脊液（CSF）。脑室扩大在疾病发作时（青年期）就已出现，值得注意的是，在子宫内检测到的孤立性轻度脑室扩大与随后出现的轻度神经发育异常有关，这些异常类似于在有精神分裂症高风险的儿童中观察到的异常。在此，我们提出神经发育过程中CP/CSF动态变化改变可能被视为精神分裂症发生发展的一个风险、致病和/或参与因素。
