通过 DISC1 将精神疾病的神经发育和突触理论联系起来。
Linking neurodevelopmental and synaptic theories of mental illness through DISC1.
机构信息
Pfizer Neuroscience, Groton, Connecticut 06437, USA.
出版信息
Nat Rev Neurosci. 2011 Nov 18;12(12):707-22. doi: 10.1038/nrn3120.
Abstract
Recent advances in our understanding of the underlying genetic architecture of psychiatric disorders has blown away the diagnostic boundaries that are defined by currently used diagnostic manuals. The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited chromosomal translocation, which segregates with major mental illnesses. In addition, many biological studies have indicated a role for DISC1 in early neurodevelopment and synaptic regulation. Given that DISC1 is thought to drive a range of endophenotypes that underlie major mental conditions, elucidating the biology of DISC1 may enable the construction of new diagnostic categories for mental illnesses with a more meaningful biological foundation.
摘要
我们对精神障碍潜在遗传结构的理解的最新进展，已经打破了目前使用的诊断手册所定义的诊断界限。精神分裂症 1 区（DISC1）基因最初是在一个遗传性染色体易位的断点处发现的，该易位与主要精神疾病一起分离。此外，许多生物学研究表明 DISC1 在早期神经发育和突触调节中发挥作用。鉴于 DISC1 被认为驱动一系列潜在的主要精神疾病的表型，阐明 DISC1 的生物学特性可能能够为精神疾病构建具有更有意义的生物学基础的新的诊断类别。
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