El Aziz Siham, Chadli Asma, Obbiba Atika, El Ghomari Hassan, Farouqi Ahmed
Department of endocrinology, diabetes and metabolism, Ibn Rochd Universitary hospital, Casablanca, Morocco.
Pan Afr Med J. 2012;12:27. Epub 2012 Jun 10.
A 56-years-old woman was referred to our unit for partially treated acromegaly. She had a high level of insulin growth factor. She did not complain of any pulmonary symptoms and was a non-smoker. Physical examination revealed clinical features of acromegaly. She had a 13 mm pituitary adenoma and was proposed for surgical intervention. Her chest X-ray showed a right paracardiac tumor. Computed tomography scan revealed a large right-sided fowler tumor. Pituitary surgery was cancelled and lobectomy after biopsy with lymph nodes excision was performed through thoracotomy. Histological study of the tumor revealed a medium differentiated epidermoid carcinoma with positive lymph nodes and extension to pleura. She was referred to chemotherapy protocol. Association between carcinoma and acromegaly has previously been reported. Most common tumors are colorectal and thyroid neoplasia. As we see in this case report, we need to consider other carcinomas in acromegalic patients like pulmonary carcinoma, despite their rarity in women.
一名56岁女性因肢端肥大症治疗不彻底被转诊至我院。她的胰岛素生长因子水平较高。她没有任何肺部症状，且不吸烟。体格检查发现有肢端肥大症的临床特征。她有一个13毫米的垂体腺瘤，建议进行手术干预。她的胸部X光显示右心旁肿瘤。计算机断层扫描显示右侧有一个大的福勒氏肿瘤。垂体手术取消，通过开胸手术进行活检及淋巴结切除术后行肺叶切除术。肿瘤的组织学研究显示为中分化表皮样癌，伴有阳性淋巴结且已侵犯胸膜。她被转诊至化疗方案。此前已有癌与肢端肥大症关联的报道。最常见的肿瘤是结直肠癌和甲状腺肿瘤。正如我们在本病例报告中所见，尽管肺癌在女性中较为罕见，但在肢端肥大症患者中我们需要考虑其他癌症，如肺癌。
