Sukhanov D S, Okovityĭ S V, Demidik S N, Ivanov A K, Romantsov M G
Eksp Klin Farmakol. 2012;75(6):40-3.
Results of investigation in a group of 91 patients with infiltrative and disseminative forms of tuberculosis are presented. It is established that, at an initial level of IFN-gamma below 100 pg/ml, a higher frequency of development of the drug-induced liver injury takes place as manifested by increasing activity of the basic markers of cytolysis. Administration of the interferon inductor (cycloferon) favors positive clinical and laboratory dynamics of the tubercular process, increases the level of endogenous IFN-gamma (especially for an initial level below 100 pg/ml), and restricts the expression of drug-induced hepatotoxicity reactions.
本文介绍了对91例浸润性和播散性肺结核患者的调查结果。已确定，在初始干扰素-γ水平低于100 pg/ml时，药物性肝损伤的发生率更高，表现为细胞溶解基本标志物活性增加。给予干扰素诱导剂（环磷酰胺）有利于结核病程的积极临床和实验室动态变化，提高内源性干扰素-γ水平（尤其是初始水平低于100 pg/ml时），并限制药物性肝毒性反应的表达。
