Wiliński Bogdan, Wiliński Jerzy, Somogyi Eugeniusz, Piotrowska Joanna, Góralska Marta
Zakład Biologii Rozwoju Człowieka, Wydział Nauk o Zdrowiu, Uniwersytet Jagielloński Collegium Medicum, Kraków, Poland.
Folia Med Cracov. 2011;51(1-4):29-35.
The interactions between calcium channel blockers' action and the endogenous hydrogen sulfide (H2S) biology are unknown. CBA strain mice were administered intraperitoneally 3 mg/kg b.w. per day or 10 mg/kg b.w. per day of amlodipine. The control group received physiological saline. The measurements of the free H2S tissue concentrations were performed with Siegel spectrophotometric modified method. There was as significant fall of H2S level in the brain and the liver in both groups. The lower amlodipine dose increased the H2S concentrations in the heart and kidneys while the higher one decreased H2S accumulation in those organs. Our experiment has shown that amlodipine interferes with H2S biology and affects its tissue concentrations in different mouse tissues.
钙通道阻滞剂的作用与内源性硫化氢（H2S）生物学之间的相互作用尚不清楚。给CBA品系小鼠腹腔注射苯磺酸氨氯地平，剂量为每天3毫克/千克体重或每天10毫克/千克体重。对照组给予生理盐水。采用改良的西格尔分光光度法测量游离H2S组织浓度。两组的大脑和肝脏中H2S水平均显著下降。较低剂量的苯磺酸氨氯地平增加了心脏和肾脏中的H2S浓度，而较高剂量则降低了这些器官中H2S的积累。我们的实验表明，苯磺酸氨氯地平干扰H2S生物学并影响其在不同小鼠组织中的组织浓度。
