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[1 Gy剂量照射的淋巴细胞与未照射淋巴细胞混合培养对染色体畸变频率的影响]

[The effect of mixed cultivation of lymphocytes irradiated at a dose of 1 Gy and non-irradiated lymphocytes on the frequency of chromosomal aberration].

作者信息

Kolesnikova I S

出版信息

Radiats Biol Radioecol. 2012 May-Jun;52(3):247-51.

PMID:22891546
Abstract

The mutual influence of irradiated (1 Gy) and non-irradiated cells was demonstrated on the model of the mixed culture oflymphocytes from opposite gender donors using chromosome aberrations (ChA) as an endpoint. The number of ChA in non-irradiated lymphocytes in mixed cultures with irradiated ones increased as compared to the corresponding monocultures. At the same time, the number of induced ChA decreased in the irradiated lymphocytes cultivated with non-irradiated ones.

摘要

以染色体畸变（ChA）作为观察终点，在来自异性供体的淋巴细胞混合培养模型上，证明了受辐照（1 Gy）细胞与未受辐照细胞之间的相互影响。与相应的单一培养相比，在与受辐照淋巴细胞的混合培养中，未受辐照淋巴细胞中的ChA数量增加。同时，与未受辐照淋巴细胞共同培养的受辐照淋巴细胞中，诱导产生的ChA数量减少。

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