Kolesnikova I S, Vorobtsova I E
Radiats Biol Radioecol. 2011 Sep-Oct;51(5):542-8.
The "bystander effect" was investigated in mixed cultures of lymphocytes from humans of opposite genders. Development of the adaptive response (AR) in non-irradiated female/male cells was estimated after adaptive pretreatment of opposite gender lymphocytes, chromosome aberrations being evaluated. Experiments were performed using two schedules of adaptive (0.05 Gy) and challenging (1 Gy) irradiations: G0-G1 and G1-G1. The results obtained indicate the development of a mediated adaptive response ("bystander effect") in the lymphocytes neighboring pre-irradiated cells, as well as the influence of a time scheme of adapting and challenging irradiations on the amount of induced chromosome aberrations in mixed cultures and a possible dependence of the adaptive response intensity on the donor gender.
在来自不同性别的人类淋巴细胞混合培养物中研究了“旁观者效应”。在对异性淋巴细胞进行适应性预处理后，评估未受照射的雌性/雄性细胞中适应性反应（AR）的发展情况，并对染色体畸变进行评估。实验采用了两种适应性（0.05 Gy）和激发性（1 Gy）照射方案：G0-G1和G1-G1。所得结果表明，在预先照射的细胞附近的淋巴细胞中存在介导的适应性反应（“旁观者效应”），以及适应性和激发性照射的时间方案对混合培养物中诱导的染色体畸变数量的影响，以及适应性反应强度可能对供体性别存在依赖性。
