Luzianina A A, Goriacheva A S, Semin Iu A, Izmest'eva O S, Deĭgin V I, Saenko A S, Zhavoronkov L P
Radiats Biol Radioecol. 2012 May-Jun;52(3):257-60.
Our work was aimed at researching into the influence of dipeptide (gamma-dGlu-dTrp) "Timodepressin" and this dipeptide-based tripeptides on the colony-forming ability of the irradiated in vitro bone marrow and hemopoietic stem cells of the normal organism. Also studied was the effect of various doses (1-1000 microg/kg) of one oftripeptides (dAla-gammadGlu-dTrp) on the output of exogenous splenic colonies in the case of its introduction 48 hours before irradiation. It is shown that the mode of influence of the preparations produced on the basis ofdipeptides dGlu-dTrp and gamma-dGlu-dTrp on the initial stages ofa hemopoiesis in the normal and irradiated organism depends on the nature of the additional amino-acid residue and its optical orientation.
我们的工作旨在研究二肽（γ-dGlu-dTrp）“替莫德辛”以及基于该二肽的三肽对正常机体体外照射骨髓和造血干细胞集落形成能力的影响。还研究了在照射前48小时引入各种剂量（1 - 1000微克/千克）的一种三肽（dAla-γ-dGlu-dTrp）对外源性脾集落产出的影响。结果表明，基于二肽dGlu-dTrp和γ-dGlu-dTrp制备的制剂对正常和受照射机体造血初期的影响方式取决于额外氨基酸残基的性质及其光学取向。
