Depoortere R, Di Scala G, Sandner G
D.N.B.C., Centre de Neurochimie du C.N.R.S., Strasbourg, France.
Brain Res Bull. 1990 Nov;25(5):723-7. doi: 10.1016/0361-9230(90)90049-6.
The effects of electrical stimulation of the "mesencephalic locomotor region" and adjacent dorsolateral tegmentum were assessed and compared in the same rats in freely moving conditions or when lightly anesthetized and suspended over a moving treadmill. In freely moving conditions, electrical brain stimulation (EBS) of this part of the mesencephalon elicited mainly aversive effects (escape reactions: violent running and explosive jumps), but also ipsiversive circling and "gnawing." On the treadmill, EBS induced flexions of hindlimbs followed by locomotion (stepping) or flexions only. In addition, it was found that locomotion and flexions on the treadmill were almost exclusively elicited by EBS of sites positive for escape reactions in freely moving conditions.
在自由活动条件下或轻度麻醉并悬吊在移动跑步机上时，对同一批大鼠评估并比较了电刺激“中脑运动区”及相邻背外侧被盖区的效果。在自由活动条件下，对中脑这一部位进行脑电刺激（EBS）主要引发厌恶效应（逃避反应：剧烈奔跑和爆发性跳跃），但也会引发同侧旋转和“啃咬”。在跑步机上，EBS会诱发后肢屈曲，随后出现运动（踏步）或仅出现屈曲。此外，还发现跑步机上的运动和屈曲几乎完全由自由活动条件下对逃避反应呈阳性的部位进行EBS所引发。
