Depoortere R, Sandner G, Di Scala G
D.N.B.C., Centre de Neurochimie du C.N.R.S. Strasbourg, France.
Physiol Behav. 1991 Feb;49(2):339-45. doi: 10.1016/0031-9384(91)90054-r.
The classical 2-lever food-reward-reinforced discrimination paradigm, although already successfully applied to study discriminative properties of positively reinforcing electrical brain stimulations (EBS), has not yet been used for negatively reinforcing (aversive) EBS. This study was aimed at assessing if such a discrimination paradigm could be used to demonstrate discriminative properties of aversive EBS of the so-called "mesencephalic locomotor region" (MLR). Fourteen rats were trained for food reward to press one lever in the presence of EBS of the MLR and the other lever in the absence of EBS. Discriminative control by EBS of the MLR was obtained in 11 rats, which were subsequently subjected to a parametric study. It was found that the discriminative properties of EBS of the MLR covaried with changes in the intensity, frequency and pulse duration of the EBS. Our data also suggest that the aversive dimension of the stimulation might constitute a component of the discriminative cue induced by these EBS.
经典的双杠杆食物奖励强化辨别范式，尽管已成功应用于研究正性强化性脑电刺激（EBS）的辨别特性，但尚未用于负性强化（厌恶性）EBS。本研究旨在评估这样一种辨别范式是否可用于证明所谓“中脑运动区”（MLR）的厌恶性EBS的辨别特性。14只大鼠接受食物奖励训练，在MLR的EBS存在时按压一个杠杆，在无EBS时按压另一个杠杆。11只大鼠获得了MLR的EBS辨别控制，随后对其进行参数研究。发现MLR的EBS辨别特性与EBS的强度、频率和脉冲持续时间的变化相关。我们的数据还表明，刺激的厌恶性维度可能构成这些EBS诱导的辨别线索的一个组成部分。
