Fraccalvieri Marco, Fierro Maria Teresa, Salomone Marco, Fava Paolo, Zingarelli Enrico M, Cavaliere Giovanni, Bernengo Maria G, Bruschi Stefano
Plastic Surgery Department, University of Turin, San Giovanni Battista di Torino, Via Cherasco 23, Turin, ItalyDepartment of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Turin, San Giovanni Battista di Torino, Via Cherasco 23, Turin, Italy.
Int Wound J. 2014 Apr;11(2):164-8. doi: 10.1111/j.1742-481X.2012.01058.x. Epub 2012 Aug 14.
Pyoderma gangrenosum (PG) is an uncommon ulcerative, non-infective chronic inflammatory skin disorder of unknown aetiology. Systemic therapies are necessary to control the associated medical diseases, and, due to the inflammatory nature of PG, topical or systemic immunosuppressant agents are effective, but wound healing is usually slow. Negative wound pressure therapy (NPWT) has become an important tool for the management of complex skin ulcers, and usage in PG has been recently described in the literature: we present four cases of classic PG in which NPWT in association with systemic therapy achieved wound healing and a drastic pain reduction.
坏疽性脓皮病（PG）是一种病因不明的罕见溃疡性、非感染性慢性炎症性皮肤病。控制相关内科疾病需要进行全身治疗，由于PG的炎症性质，局部或全身免疫抑制剂有效，但伤口愈合通常缓慢。负压伤口治疗（NPWT）已成为治疗复杂皮肤溃疡的重要工具，近期文献中已有关于其在PG中应用的描述：我们报告4例典型PG病例，其中NPWT联合全身治疗实现了伤口愈合并显著减轻了疼痛。
