Dillingham Claire Sanger, Jorizzo Joseph
At the Wake Forest Baptist Medical University in Winston-Salem, North Carolina, Claire Sanger Dillingham, DO, is Associate Professor, Plastic and Reconstructive Surgery Department; and Joseph Jorizzo, MD, is Professor, Dermatology Department. The authors have disclosed no financial relationships related to this article. Submitted March 21, 2018; accepted in revised form June 12, 2018.
Adv Skin Wound Care. 2019 Feb;32(2):70-76. doi: 10.1097/01.ASW.0000546120.32681.bc.
Pyoderma gangrenosum (PG) is a rare disease that presents as painful ulcerations with inflammation and undermining at the borders. The ulcers can occur anywhere on the body but are most commonly seen on the lower extremities. The etiology of PG is unknown, and there are no definitive diagnostic criteria; PG is a diagnosis of exclusion, which can present serious delays in treatment.Patients should be treated with an interdisciplinary approach with aggressive immunosuppression, treatment of any comorbidities, maximization of nutrition status, reconstructive surgery for treatment of the wound, and physical therapy for deconditioning.This article presents a case study of one patient treated with a porcine urinary bladder matrix and negative-pressure wound therapy; this treatment combination provided pain relief, coverage of the wound, an acceptable aesthetic outcome, and long-term stability.
坏疽性脓皮病（PG）是一种罕见疾病，表现为伴有炎症且边缘呈潜行性的疼痛性溃疡。溃疡可发生于身体的任何部位，但最常见于下肢。PG的病因不明，且没有明确的诊断标准；PG是一种排除性诊断，这可能导致治疗严重延误。患者应采用多学科方法进行治疗，积极进行免疫抑制、治疗任何合并症、优化营养状况、通过重建手术治疗伤口以及进行物理治疗以改善身体状况。本文介绍了一例使用猪膀胱基质和负压伤口治疗的患者的病例研究；这种治疗组合缓解了疼痛，覆盖了伤口，取得了可接受的美学效果，并实现了长期稳定性。
