Vainionpää Mari, Salla Kati, Restitutti Flávia, Raekallio Marja, Junnila Jouni, Snellman Marjatta, Vainio Outi
Department of Equine and Small Animal Medicine, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Helsinki, Finland 4Pharma Ltd, Espoo, Finland.
Vet Anaesth Analg. 2013 Mar;40(2):142-8. doi: 10.1111/j.1467-2995.2012.00768.x. Epub 2012 Aug 14.
To record, with a thermal camera, peripheral temperature changes during different sedation protocols and to relate the results to changes in the rectal temperature.
Randomized crossover part-blinded experimental study.
Eight healthy purpose-bred neutered Beagles (two females and six males) weight 14.5 ± 1.6 kg (mean ± SD) and aged 3-4 years.
Each dog was sedated four times. Treatments were medetomidine 20 μg kg(-1) and butorphanol 0.1 mg kg(-1) (MB) with or without MK-467 500 μg kg(-1) (MK). Both drug combinations were administered IV and IM as separate treatments. A thermal camera (T425, FLIR) with a resolution of 320 by 240 was used for imaging. The dogs were placed in lateral recumbency on an insulated mattress. Digital (DFT) and metatarsal footpad temperatures (MFT) were measured with thermography. Thermograms and rectal temperature (RT) were taken before and at 3, 10, 20, 30, 45 and 60 minutes after treatment.
At 60 minutes after drug administration, MFT was higher (p < 0.001) after MB+MK (34.5 ± 1.1 IV, 34.8 ± 0.5 IM) than MB (31.1 ± 2.9 IV, 30.5 ± 3.6 IM), DFT was higher (p < 0.001) after MB+MK (33.6 ± 1.4 IV, 34.0 ± 0.6 IM) than MB (26.7 ± 1.4 IV, 26.7 ± 2.5 IM), and RT was lower (p < 0.001) after MB+MK (36.7 ± 0.8 IV, 36.9 ± 0.3 IM) than MB (37.5 ± 0.3 IV, 37.4 ± 0.4 IM), with both routes. The change from baseline was greater with MB+MK than MB in all variables.
Superficial temperature changes can be seen and detected with thermography. MK-467 used with MB resulted in increased superficial temperatures and a decline in rectal temperature compared to MB alone.
The sedation protocol may influence core temperature loss, and may also have an effect on thermographic images.
使用热成像仪记录不同镇静方案期间的外周温度变化，并将结果与直肠温度变化相关联。
随机交叉半盲实验研究。
八只健康的经专门培育并绝育的比格犬（两只雌性和六只雄性），体重14.5±1.6千克（均值±标准差），年龄3 - 4岁。
每只犬接受四次镇静。治疗方法为美托咪定20μg/kg(-1)和布托啡诺0.1mg/kg(-1)（MB），加或不加MK - 467 500μg/kg(-1)（MK）。两种药物组合分别通过静脉注射和肌肉注射给药。使用分辨率为320×240的热成像仪（T425，FLIR）进行成像。犬侧卧于隔热床垫上。通过热成像测量趾背温度（DFT）和跖部足垫温度（MFT）。在治疗前以及治疗后3、10、20、30、45和60分钟拍摄热成像图和直肠温度（RT）。
给药后60分钟，MB + MK组（静脉注射34.5±1.1，肌肉注射34.8±0.5）的MFT高于MB组（静脉注射31.1±2.9，肌肉注射30.5±3.6）（p < 0.001），MB + MK组（静脉注射33.6±1.4，肌肉注射34.0±0.6）的DFT高于MB组（静脉注射26.7±1.4，肌肉注射26.7±（此处原文有误，应为2.5）2.5）（p < 0.001），且MB + MK组（静脉注射36.7±0.8，肌肉注射36.9±0.3）的RT低于MB组（静脉注射37.5±0.3，肌肉注射37.4±0.4）（p < 0.001），两种给药途径均如此。在所有变量中，MB + MK组相对于MB组从基线的变化更大。
热成像可以观察和检测到体表温度变化。与单独使用MB相比，MB与MK - 467联合使用导致体表温度升高，直肠温度下降。
镇静方案可能影响核心体温下降，也可能对热成像图像产生影响。
