色氨酸可增加饥饿大鼠下丘脑外侧的细胞外5-羟色胺（血清素）水平。

Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats.

作者信息

Schwartz D H, Hernandez L, Hoebel B G

机构信息

Department of Psychology, Princeton University, NJ 08544-1010.

出版信息

Brain Res Bull. 1990 Dec;25(6):803-7. doi: 10.1016/0361-9230(90)90174-x.

DOI:10.1016/0361-9230(90)90174-x

PMID:2289170

Abstract

Although it is well established that increases in tryptophan availability can increase brain serotonin synthesis, the effect of tryptophan loads on serotonin release is not as clear. We have used in vivo microdialysis in order to monitor extracellular serotonin in the lateral hypothalamus to examine this issue. Tryptophan methyl ester (100 mg/kg IP) was administered to ad lib-fed and 48-h food-deprived rats. The results suggest that a peripheral tryptophan load can elevate extracellular serotonin in food-deprived subjects more effectively than in food-replete subjects.

摘要

虽然已有充分证据表明色氨酸可用性增加可提高大脑中血清素的合成，但色氨酸负荷对血清素释放的影响尚不清楚。我们采用体内微透析法监测下丘脑外侧细胞外血清素水平，以研究此问题。对自由进食和禁食48小时的大鼠腹腔注射色氨酸甲酯（100mg/kg）。结果表明，外周色氨酸负荷在禁食的实验对象中比在进食充足的实验对象中能更有效地提高细胞外血清素水平。