Guillamón A, Calés J M, Rodriguez-Zafra M, Perez-Laso C, Caminero A, Izquierdo M A, Segovia S
Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Madrid, Spain.
Brain Res Bull. 1990 Dec;25(6):913-6. doi: 10.1016/0361-9230(90)90187-5.
The effects of prenatal and/or early postnatal diazepam (DZ) administration on open field activity and continuously reinforced lever-pressing response were studied. Rat pups of both sexes were prenatally (during the last week of pregnancy) and/or postnatally (from the day of birth to day 16) daily exposed to a 2.5 mg/kg dose of DZ. At the age of 60 days all groups were tested in the open field for 5 consecutive days and thirty days later they were studied in a continuously reinforced lever-pressing situation during four consecutive days. In the open field test, females showed greater activity than males and prenatal and/or early postnatal DZ treatments did not alter this sexual dimorphism, although all treatments decreased the open field activity in both male and female 60-day-old rats. In the Skinner box, 90-day-old males presented higher rates of lever-pressing response than females, and only the early postnatal DZ treatment was effective in altering this sexual dimorphism, by decreasing the male's but not female's rates of response. These results are discussed in regard to the possible interaction between DZ and gonadal hormones during the early sexual differentiation period.
研究了产前和/或产后早期给予地西泮（DZ）对旷场活动和持续强化杠杆按压反应的影响。对雌雄大鼠幼崽在产前（妊娠最后一周）和/或产后（从出生日至第16天）每天给予2.5mg/kg剂量的DZ。60日龄时，所有组连续5天在旷场中进行测试，30天后，连续4天在持续强化杠杆按压情况下对它们进行研究。在旷场试验中，雌性比雄性表现出更大的活动量，产前和/或产后早期给予DZ并未改变这种性别差异，尽管所有处理均降低了60日龄雌雄大鼠的旷场活动量。在斯金纳箱中，90日龄雄性大鼠的杠杆按压反应率高于雌性，只有产后早期给予DZ的处理有效地改变了这种性别差异，即降低了雄性而非雌性的反应率。就DZ与性腺激素在早期性别分化期可能的相互作用对这些结果进行了讨论。
