Rodriguez-Zafra M, De Blas M R, Perez-Laso C, Cales J M, Guillamon A, Segovia S
Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria, Madrid, Spain.
Neurotoxicol Teratol. 1993 Mar-Apr;15(2):139-44. doi: 10.1016/0892-0362(93)90072-v.
Diazepam (DZ) administration over prenatal, postnatal, and pre plus postnatal periods altered the normal expression of the morphological sex differences of the LC. Males were affected only by the prenatal exposure and the effect of this exposure produced an increase in the volume and neuron number of male's LC. By contrast, females were affected by both pre and postnatal treatments and the effect of this exposure resulted in a decrease in the volume and neuron number of female's LC. However, pre plus postnatal treatment did not affect female's LC.
在产前、产后以及产前加产后阶段给予地西泮（DZ）会改变蓝斑形态学性别差异的正常表达。雄性仅受产前暴露影响，这种暴露的影响导致雄性蓝斑的体积和神经元数量增加。相比之下，雌性受产前和产后治疗两者的影响，这种暴露的影响导致雌性蓝斑的体积和神经元数量减少。然而，产前加产后治疗并未影响雌性蓝斑。
