Wo Saet Byul, Lee Jun Hwa, Lee Yong Ju, Sung Tae-Jung, Lee Kon Hee, Kim Sung Koo
Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University, School of Medicine, Republic of Korea.
Brain Dev. 2013 Apr;35(4):307-11. doi: 10.1016/j.braindev.2012.07.014. Epub 2012 Aug 11.
The aim of the present study was to investigate the correlation between epileptiform discharges on EEGs after febrile seizures and the prognosis of patients in terms of the development of epilepsy and recurrence of febrile seizures. This study also evaluated the characteristics of epileptiform discharges and EEG changes on follow-up examination. methods: This study consisted of 36 children who presented to our hospital with febrile seizures and whose electroencephalograms (EEG) showed epileptiform discharges. The development of epilepsy and the recurrence of febrile seizures were compared between the study group (n=36) and the control group (n=87), which included children with febrile seizure but with normal EEG findings.
No significant correlation was detected between the recurrence rate of febrile seizures in patients with normal EEG (23 out of 87, 26.4%) findings and that of patients whose EEGs showed epileptiform discharges (12 out of 36, 33.3%) [adjusted OR 0.67 (0.26-1.68)]. However, 9 (25.0%) out of 36 patients with epileptiform discharges on EEG had epilepsy compared to 2 patients (2.3%) in the control group. The correlation was statistically significant [crude OR 10.88 (2.47-47.88) and adjusted OR 8.75 (1.49-51.6)].
Epileptiform discharges on the EEGs of patients with febrile seizures are important predictive risk factors of the development of epilepsy.
本研究旨在探讨热性惊厥后脑电图上的癫痫样放电与患者癫痫发生及热性惊厥复发预后之间的相关性。本研究还评估了随访检查时癫痫样放电的特征及脑电图变化。方法：本研究纳入了36例因热性惊厥就诊于我院且脑电图显示癫痫样放电的儿童。将研究组（n = 36）与对照组（n = 87，包括热性惊厥但脑电图结果正常的儿童）进行癫痫发生情况及热性惊厥复发情况的比较。
脑电图正常患者（87例中的23例，26.4%）的热性惊厥复发率与脑电图显示癫痫样放电患者（36例中的12例，33.3%）的热性惊厥复发率之间未检测到显著相关性[校正比值比0.67（0.26 - 1.68）]。然而，脑电图有癫痫样放电的36例患者中有9例（25.0%）发生癫痫，而对照组中有2例（2.3%）发生癫痫。相关性具有统计学意义[粗比值比10.88（2.47 - 47.88），校正比值比8.75（1.49 - 51.6）]。
热性惊厥患者脑电图上的癫痫样放电是癫痫发生的重要预测危险因素。
