Sjögreen L, Kiliaridis S
Mun-H-Center Orofacial Resource Centre for Rare Diseases and Department of Speech Pathology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at Gothenburg University, Sweden.
J Laryngol Otol. 2012 Sep;126(9):902-6. doi: 10.1017/S0022215112001429.
Earlier studies have shown that individuals with thalidomide embryopathy can have skeletal deformities, ear and eye aberrations, and facial palsy. This study aimed to survey the frequency and characteristics of facial palsy in this group of individuals.
Thirty-one individuals with thalidomide embryopathy (age range, 45-47 years) and 25 healthy adults (age range, 41-56 years; mean age ± standard deviation, 49 ± 4.2 years).
Voluntary facial movements, lip force and three-dimensional lip motion analysis.
Four of the thalidomide embryopathy individuals (13 per cent) had congenital facial palsy. All four had eye aberrations, three had ear anomalies and one had a limb anomaly. Individuals with thalidomide embryopathy without a clinical diagnosis of facial impairment had significantly weaker lips and more restricted lip mobility than healthy controls. This study contributes to the overall knowledge of thalidomide embryopathy by adding a description of how facial expression can be affected in this condition.
早期研究表明，患有沙利度胺胚胎病的个体可能出现骨骼畸形、耳眼异常和面瘫。本研究旨在调查该组个体中面瘫的发生率及特征。
31名患有沙利度胺胚胎病的个体（年龄范围45 - 47岁）和25名健康成年人（年龄范围41 - 56岁；平均年龄±标准差，49 ± 4.2岁）。
面部自主运动、唇部力量及三维唇部运动分析。
4名患有沙利度胺胚胎病的个体（13%）患有先天性面瘫。这4人均有眼异常，3人有耳部异常，1人有肢体异常。未临床诊断为面部功能障碍的沙利度胺胚胎病个体，其唇部力量明显弱于健康对照，唇部活动度也更受限。本研究通过描述沙利度胺胚胎病如何影响面部表情，为该病的整体知识体系做出了贡献。
