Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA.
J Am Acad Dermatol. 2012 Dec;67(6):1302-9. doi: 10.1016/j.jaad.2012.05.041. Epub 2012 Aug 11.
Complications associated with Mohs surgery have been evaluated by single-surgeon studies. While these studies provide evidence for the safety of the procedure, prospective, multicenter studies afford a higher level of clinical evidence and establish further the safety profile of Mohs surgery in the ambulatory setting.
This study was designed to prospectively evaluate major and minor complications as well as postoperative pain associated with Mohs surgery.
A multicenter prospective cohort study was conducted evaluating the rate of major and minor complications as well as postoperative pain associated with the treatment of skin cancer using Mohs surgery in 1550 patients with 1792 tumors. Follow-up was obtained in 1709 of the 1792 tumors treated (95.3%).
No major complications occurred during Mohs surgery or reconstruction. A total of 44 (2.6%) minor primary postoperative complications occurred during the study. On a scale from 0 to 10, the average peak postoperative pain level was 1.99.
Limitations of the study include the variability of practice patterns across practice sites as well as the 4.7% of patients lost to follow-up.
Mohs surgery is performed with a high degree of safety and is well tolerated by patients.
Mohs 手术相关并发症已通过单外科医生研究进行了评估。虽然这些研究为该手术的安全性提供了证据，但前瞻性、多中心研究提供了更高水平的临床证据，并进一步确定了 Mohs 手术在门诊环境中的安全性。
本研究旨在前瞻性评估 Mohs 手术相关的主要和次要并发症以及术后疼痛。
进行了一项多中心前瞻性队列研究，评估了 1550 例 1792 个肿瘤患者接受 Mohs 手术治疗皮肤癌的主要和次要并发症以及术后疼痛的发生率。对 1792 个治疗肿瘤中的 1709 个进行了随访（95.3%）。
在 Mohs 手术或重建过程中未发生主要并发症。研究期间共发生 44 例（2.6%）轻微原发性术后并发症。平均术后疼痛峰值评分为 1.99（评分范围为 0 至 10）。
该研究的局限性包括各实践地点的实践模式差异以及 4.7%的失访患者。
Mohs 手术具有高度的安全性，患者可耐受。
