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解析皮肤癌:皮肤癌管理中诊断、治疗策略及新兴治疗途径的全面审视

Unraveling Skin Carcinoma: A Comprehensive Examination of Diagnosis, Treatment Strategies, and Emerging Therapeutic Avenues in Skin Cancer Management.

作者信息

Bhadouria Namrata, Alam Aftab, Kaur Awaneet

机构信息

Department of Pharmacy, School of medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

出版信息

Pharm Nanotechnol. 2025;13(4):648-664. doi: 10.2174/0122117385282163240220072251.

DOI:10.2174/0122117385282163240220072251
PMID:38468531
Abstract

Cancer that begins in the skin is by far the most common kind of skin cancer found everywhere in the globe. It is further subdivided into groups, such as basal cell carcinoma and cutaneous squamous cell carcinoma, in addition to other, less common types of skin cancer. In this article, the diagnostic aspects that need to be taken into consideration when utilizing these new guidelines, go over the essential features of cutaneous SCC, conduct an analysis of recent changes in the category of cutaneous SCC, and speak about recent advancements in the categorization of cutaneous SCC. Over the course of the past decade, photodynamic therapy has developed into a potentially effective treatment for a variety of solid tumors that may be found in people. The combination of metallic nanoparticles and phytoconstituents as a therapy for skin cancer has the potential to be more successful than each treatment used independently. In this article, the various treatment modalities for skin cancer were examined. This included excision surgery, Mohs surgery, radiation therapy, and immunotherapy. These were then followed by targeted therapy or immunotherapy, in addition to surgery, radiation, or photodynamic therapy. Since excision surgery is the most typical procedure used to eradicate skin cancer, we concentrate on it in particular.

摘要

起源于皮肤的癌症是目前全球最常见的皮肤癌类型。它还可进一步细分为不同类别,如基底细胞癌和皮肤鳞状细胞癌,此外还有其他不太常见的皮肤癌类型。在本文中,我们将探讨使用这些新指南时需要考虑的诊断方面,阐述皮肤鳞状细胞癌的基本特征,分析皮肤鳞状细胞癌分类的近期变化,并介绍皮肤鳞状细胞癌分类的最新进展。在过去十年中,光动力疗法已发展成为一种对人类多种实体瘤可能有效的治疗方法。金属纳米颗粒和植物成分联合治疗皮肤癌有可能比单独使用每种治疗方法更成功。本文研究了皮肤癌的各种治疗方式,包括切除手术、莫氏手术、放射治疗和免疫治疗。除手术、放疗或光动力疗法外,还包括靶向治疗或免疫治疗。由于切除手术是根除皮肤癌最常用的方法,我们将特别关注它。

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本文引用的文献

1
Skin Cancer Detection Using Deep Learning-A Review.基于深度学习的皮肤癌检测——综述
Diagnostics (Basel). 2023 May 30;13(11):1911. doi: 10.3390/diagnostics13111911.
2
Clinicopathological Factors Influencing Resection Margin Involvement During Mohs Micrographic Surgery for Skin Tumors.影响皮肤肿瘤 Mohs 显微外科手术切缘累及的临床病理因素。
Anticancer Res. 2023 Jun;43(6):2707-2715. doi: 10.21873/anticanres.16437.
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Advancements in nanoparticle-based treatment approaches for skin cancer therapy.基于纳米粒子的皮肤癌治疗方法的进展。
Mol Cancer. 2023 Jan 12;22(1):10. doi: 10.1186/s12943-022-01708-4.
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Precision medicine: Ray of hope in overcoming cancer multidrug resistance.精准医学:克服癌症多药耐药的希望之光。
Drug Resist Updat. 2022 Dec;65:100889. doi: 10.1016/j.drup.2022.100889. Epub 2022 Nov 9.
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An insight on topically applied formulations for management of various skin disorders.关于局部应用制剂治疗各种皮肤疾病的见解。
J Biomater Sci Polym Ed. 2022 Dec;33(18):2406-2432. doi: 10.1080/09205063.2022.2103625. Epub 2022 Jul 27.
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Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022. Merkel 细胞癌的诊断和治疗:基于欧洲共识的跨学科指南-2022 年更新。
Eur J Cancer. 2022 Aug;171:203-231. doi: 10.1016/j.ejca.2022.03.043. Epub 2022 Jun 19.
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Research progress of microneedles in the treatment of melanoma.微针在黑色素瘤治疗中的研究进展。
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Mechanisms of Immunotherapy Resistance in Cutaneous Melanoma: Recognizing a Shapeshifter.皮肤黑色素瘤免疫治疗耐药机制:认识一个善变者。
Front Oncol. 2022 Apr 19;12:880876. doi: 10.3389/fonc.2022.880876. eCollection 2022.
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Cancer statistics, 2022.癌症统计数据,2022 年。
CA Cancer J Clin. 2022 Jan;72(1):7-33. doi: 10.3322/caac.21708. Epub 2022 Jan 12.
10
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.2010 年至 2019 年 29 种癌症的发病率、死亡率、生命损失年数、失能生存年数和伤残调整生命年:2019 年全球疾病负担研究的系统分析。
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