Pipili Chrysoula, Pantelias Konstantinos, Papaioannou Nikos, Paraskevakou Helen, Grapsa Eirini
Department of Nephrology, Aretaieion University Hospital, Athens, Greece.
Transfus Apher Sci. 2012 Oct;47(2):155-8. doi: 10.1016/j.transci.2012.06.018. Epub 2012 Aug 11.
A young patient with hemolytic-uremic syndrome and malignant hypertension with serious deterioration of renal function is described whose biopsy specimen showed additional IgA mesangial deposits. The patient responded to steroid treatment and to plasma exchange therapy without the need of hemodialysis sessions. In the following years, he achieved clinical remission and his blood pressure was in normal ranges without any further complications. IgA glomerulonephritis is rarely associated to hemolytic-uremic syndrome and malignant hypertension, with only a few previously described cases. We present an overview of potential pathophysiological connections between these diseases.
本文描述了一名患有溶血性尿毒症综合征和恶性高血压且肾功能严重恶化的年轻患者，其活检标本显示有额外的IgA系膜沉积物。该患者对类固醇治疗和血浆置换疗法有反应，无需进行血液透析。在接下来的几年里，他实现了临床缓解，血压处于正常范围，没有任何进一步的并发症。IgA肾小球肾炎很少与溶血性尿毒症综合征和恶性高血压相关，此前仅有少数病例报道。我们概述了这些疾病之间潜在的病理生理联系。
