Nathoo Rajiv K, Harb Jennifer N, Auerbach Jena, Guo Ruifeng, Vincek Vladimir, Motaparthi Kiran
Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
Department of Pathology, University of Florida College of Medicine, Gainesville, Florida.
J Cutan Pathol. 2017 Dec;44(12):1064-1069. doi: 10.1111/cup.13034. Epub 2017 Sep 19.
Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life-threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings.
钙过敏是一种罕见的伴有血栓形成的血管钙化综合征，最常发生于终末期肾病患者，且常常预示着预后不佳。非尿毒症性钙过敏（NUC）很少见；在这种情况下，有力支持诊断的组织学检查对于确诊至关重要。在此，我们描述2例与弹性假黄瘤样改变相关的NUC病例，这在最初的非诊断性活检标本及随后的诊断性活检标本中均有发现。这种不寻常但有帮助的组织学发现可能有助于在组织病理学血管改变不明显或缺乏典型临床或实验室检查结果的情况下，对这种潜在的危及生命的疾病进行早期诊断和治疗。
