Teagasc Food Research Centre, Cork, Ireland.
Gut Microbes. 2012 Sep-Oct;3(5):468-73. doi: 10.4161/gmic.21417. Epub 2012 Aug 15.
A recent comparative genomic hybridization study in our laboratory revealed considerable plasticity within the bacteriocin locus of gastrointestinal strains of Lactobacillus salivarius. Most notably, these analyses led to the identification of two novel unmodified bacteriocins, salivaricin L and salivaricin T, produced by the neonatal isolate L. salivarius DPC6488 with immunity, regulatory and export systems analogous to those of abp118, a two-component bacteriocin produced by the well characterized reference strain L. salivarius UCC118. In this addendum we discuss the intraspecific diversity of our seven bacteriocin-producing L. salivarius isolates on a genome-wide level, and more specifically, with respect to their salivaricin loci.
本实验室最近的比较基因组杂交研究显示，唾液乳杆菌胃肠道分离株的细菌素基因座具有相当大的可塑性。这些分析特别导致了两种新型未修饰细菌素的鉴定，即由新生儿分离株 L. salivarius DPC6488 产生的 salivaricin L 和 salivaricin T，其免疫、调节和输出系统类似于由 well characterized reference strain L. salivarius UCC118 产生的双组分细菌素 abp118。在本增刊中，我们讨论了我们的七种产细菌素唾液乳杆菌分离株在全基因组水平上的种内多样性，更具体地说，是关于它们的 salivaricin 基因座。
