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载万古霉素聚-l-乳酸和聚氧化乙烯微球在骨修复中的应用：一项体内研究。

The use of vancomycin-loaded poly-l-lactic acid and poly-ethylene oxide microspheres for bone repair: an in vivo study.

机构信息

Experimental Orthopaedics, Department of Orthopaedic Surgery, Medical University Innsbruck, Austria.

出版信息

Clinics (Sao Paulo). 2012 Jul;67(7):793-8. doi: 10.6061/clinics/2012(07)15.

DOI:10.6061/clinics/2012(07)15
PMID:22892925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3400171/
Abstract

OBJECTIVE

The aim of this study was to investigate bone repair after the implantation of vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres compared with vancomycin-unloaded poly-L-lactic acid/poly-ethylene oxide microspheres.

METHODS

Poly-L-lactic acid/poly-ethylene oxide microspheres were implanted in rat tibiae and evaluated for periods of 2, 4, 8, and 12 days and 4, 8, 16, and 32 weeks. The groups implanted with vancomycin-loaded and vancomycin-unloaded microspheres were compared. Histopathologic (semi-quantitative) and histomorphometric analyses were performed to evaluate the bone formation process.

RESULTS

During the first period (second day), fibrin and hemorrhaging areas were observed to be replaced by granulation tissue around the microspheres. Woven bone formation with progressive maturation was observed. All of the histopathological findings, evaluated by a semi-quantitative assay and a quantitative analysis (percentage of bone formation), were similar between the two groups.

CONCLUSION

Vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres are a good bone substitute candidate for bone repair. Local antibiotic therapy using vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres should be considered after the microbiological evaluation of its efficacy.

摘要

目的

本研究旨在探讨万古霉素载药聚乳酸/聚氧化乙烯微球植入后的骨修复情况，并与未载药的聚乳酸/聚氧化乙烯微球进行比较。

方法

将聚乳酸/聚氧化乙烯微球植入大鼠胫骨中，分别在 2、4、8 和 12 天以及 4、8、16 和 32 周进行评估。对比植入载药和未载药微球的两组。通过组织病理学（半定量）和组织形态计量学分析来评估骨形成过程。

结果

在第一个时期（第 2 天），观察到微球周围的纤维蛋白和出血区域被肉芽组织取代。观察到编织骨形成并逐渐成熟。两种微球的所有组织病理学发现（通过半定量检测和定量分析（骨形成百分比）评估）均相似。

结论

万古霉素载药聚乳酸/聚氧化乙烯微球是一种良好的骨修复候选材料。在评估其疗效的微生物学之后，应考虑使用万古霉素载药聚乳酸/聚氧化乙烯微球进行局部抗生素治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/2b69869512d8/cln-67-07-793-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/7c4c2fa6c71d/cln-67-07-793-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/a2834cc5f3bb/cln-67-07-793-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/aa215959939d/cln-67-07-793-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/34323d7e73dc/cln-67-07-793-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/e807815702d1/cln-67-07-793-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/2b69869512d8/cln-67-07-793-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/7c4c2fa6c71d/cln-67-07-793-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/a2834cc5f3bb/cln-67-07-793-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/aa215959939d/cln-67-07-793-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/34323d7e73dc/cln-67-07-793-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/e807815702d1/cln-67-07-793-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/277a/3400171/2b69869512d8/cln-67-07-793-g006.jpg

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本文引用的文献

1
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J Mater Sci Mater Med. 2008 Jul;19(7):2699-704. doi: 10.1007/s10856-008-3397-2. Epub 2008 Feb 19.
2
Poly-L-lactic acid: an overview.聚左旋乳酸：综述
J Drugs Dermatol. 2006 May;5(5):436-40.
3
Controlled release systems based on poly(lactic acid). An in vitro and in vivo study.
J Mater Sci Mater Med. 2000 Jun;11(6):393-7. doi: 10.1023/a:1008990109419.
4
In vivo study of biodegradable alginate antibiotic beads in rabbits.可生物降解藻酸盐抗生素珠在兔体内的研究。
J Orthop Res. 2004 May;22(3):592-9. doi: 10.1016/j.orthres.2003.09.001.
5
Allograft bone. The influence of processing on safety and performance.
Orthop Clin North Am. 1999 Oct;30(4):571-81. doi: 10.1016/s0030-5898(05)70110-3.
6
Physiology and pathophysiology of bone remodeling.骨重塑的生理学与病理生理学
Clin Chem. 1999 Aug;45(8 Pt 2):1353-8.
7
Antimicrobial treatment of chronic osteomyelitis.
Clin Orthop Relat Res. 1999 Mar(360):47-65. doi: 10.1097/00003086-199903000-00008.
8
Polycaprolactone/glass bioabsorbable implant in a rabbit humerus fracture model.聚己内酯/玻璃生物可吸收植入物在兔肱骨骨折模型中的应用
J Biomed Mater Res. 1997 Sep 15;36(4):536-41. doi: 10.1002/(sici)1097-4636(19970915)36:4<536::aid-jbm12>3.0.co;2-8.
9
Antibiotic-loaded hydroxyapatite blocks in the treatment of experimental osteomyelitis in rats.载抗生素羟基磷灰石块治疗大鼠实验性骨髓炎
J Med Microbiol. 1997 Sep;46(9):779-83. doi: 10.1099/00222615-46-9-779.
10
Preparation and characterization of poly(epsilon-caprolactone) polymer blends for the delivery of proteins.
Biomaterials. 1995 Nov;16(17):1297-303. doi: 10.1016/0142-9612(95)91044-y.