TERT-CLPTM1L rs401681[C]等位基因与非黑色素瘤皮肤癌风险的关联：一项包含 45184 例受试者的荟萃分析。
Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects.
机构信息
Department of Hygiene Toxicology, Jilin University, Jilin, China.
Department of Oncology, Tianjin Medical University, Tianjin, China.
出版信息
Arch Dermatol Res. 2013 Jan;305(1):49-52. doi: 10.1007/s00403-012-1275-8. Epub 2012 Aug 15.
Single-nucleotide polymorphism of CLPTM1L-rs401681(C > T) at the 5p15.33 locus is significantly associated with cancer risk as reported in genome-wide association studies, but the reported studies for non-melanoma skin cancer (NMSC) are inconclusive. To assess the association between rs401681[C] allele and NMSC risk, we performed this meta-analysis with four case-control studies involving 5,469 cases and 39,715 controls. Our meta-analysis showed that rs401681[C] allele was associated with NMSC susceptibility in the overall subjects (C vs. T, OR 1.13, 95 % CI 1.07-1.20). In the stratified analysis, the rs401681[C] allele confers susceptibility in Icelanders (C vs. T, OR 1.15, 95 % CI 1.06-1.26) and non-Icelanders (C vs. T, OR 1.13, 95 % CI 1.03-1.24). In the subtype analysis, we found that rs401681[C] allele was a risk factor for BCC, but not SCC in the overall subjects.
在全基因组关联研究中，CLPTM1L-rs401681(C>T) 单核苷酸多态性与癌症风险显著相关，但已报道的非黑色素瘤皮肤癌 (NMSC) 的研究结果尚无定论。为了评估 rs401681[C]等位基因与 NMSC 风险之间的关联，我们进行了这项荟萃分析，共纳入了 4 项病例对照研究，涉及 5469 例病例和 39715 例对照。我们的荟萃分析表明，rs401681[C]等位基因与总体 NMSC 易感性相关（C 对 T，OR 1.13，95%CI 1.07-1.20）。在分层分析中，rs401681[C]等位基因在冰岛人群（C 对 T，OR 1.15，95%CI 1.06-1.26）和非冰岛人群（C 对 T，OR 1.13，95%CI 1.03-1.24）中与 NMSC 易感性相关。在亚组分析中，我们发现 rs401681[C]等位基因是总体 NMSC 的一个危险因素，但不是 SCC 的危险因素。
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