Suryadevara Manika, Tabarani Christy M, Bartholoma Nadine, Rosenberg Helene F, Domachowske Joseph B
SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Clin Pediatr (Phila). 2012 Dec;51(12):1164-7. doi: 10.1177/0009922812456736. Epub 2012 Aug 14.
Although fever is common in neutropenic children, a microbiological etiology is determined in only 15% to 30% of cases. The authors investigated the frequency of respiratory virus detection in the upper airways of febrile neutropenic children with negative bacterial cultures.
This is a 3-year prospective study of children younger than 19 years, hospitalized with febrile neutropenia and negative bacterial cultures. Respiratory samples were obtained for amplification of viral nucleic acids via Luminex xTAG technology.
There were 50 febrile neutropenic episodes among 42 patients. Respiratory viruses were detected in 26 (52%) febrile episodes. A single virus was detected in 22 febrile episodes; multiple viruses were detected in the remaining 4. Rhinovirus/Enterovirus was most frequently detected.
Respiratory viruses were detected frequently in nasopharyngeal samples from febrile neutropenic patients with negative bacterial cultures, thus providing an impetus to determine the relationship between virus detection, infection, and pathology in this unique patient population.
尽管发热在中性粒细胞减少的儿童中很常见，但仅15%至30%的病例能确定微生物病因。作者调查了细菌培养阴性的发热性中性粒细胞减少儿童上呼吸道中呼吸道病毒的检出频率。
这是一项针对19岁以下因发热性中性粒细胞减少症住院且细菌培养阴性的儿童进行的为期3年的前瞻性研究。通过Luminex xTAG技术获取呼吸道样本以扩增病毒核酸。
42例患者中出现50次发热性中性粒细胞减少发作。26次（52%）发热发作中检测到呼吸道病毒。22次发热发作中检测到单一病毒；其余４次检测到多种病毒。鼻病毒/肠道病毒最常被检测到。
在细菌培养阴性的发热性中性粒细胞减少患者的鼻咽样本中经常检测到呼吸道病毒，从而促使人们去确定在这一独特患者群体中病毒检测、感染和病理之间的关系。
