24个月以下住院儿童急性发热性呼吸道疾病的病毒病因
Viral etiology of acute febrile respiratory illnesses in hospitalized children younger than 24 months.
作者信息
Suryadevara Manika, Cummings Erin, Bonville Cynthia A, Bartholoma Nadine, Riddell Scott, Kiska Deanna, Rosenberg Helene F, Domachowske Joseph B
机构信息
Department of Pediatrics, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
出版信息
Clin Pediatr (Phila). 2011 Jun;50(6):513-7. doi: 10.1177/0009922810394834. Epub 2011 Jan 23.
BACKGROUND
Respiratory infections are a leading cause of pediatric hospitalizations. This study investigated whether virus-virus or virus-Bordetella co-infections are more frequent or more severe than previously recognized.
METHODS
This is a 3-year prospective study of children younger than 24 months hospitalized with a febrile respiratory illness. Viral pathogens were detected using multiplex polymerase chain reaction (PCR), enzyme-linked immunoassays, and/or viral cultures from nasopharyngeal samples. Bordetella infections were detected by PCR.
RESULTS
A total of 201 patients were enrolled. Respiratory viruses were detected in 187 (93%) patients, with 52 (28%) multipathogen infections. The most common viruses detected were respiratory syncytial virus and rhinovirus/enterovirus. There were no differences in illness severity when comparing patients infected with one pathogen and those with multipathogen infection.
CONCLUSION
Virus co-infection in young children hospitalized with an acute febrile respiratory infection is common but does not appear to be associated with illness severity.
背景
呼吸道感染是儿科住院的主要原因。本研究调查了病毒-病毒或病毒-博德特氏菌共感染是否比以前认识到的更常见或更严重。
方法
这是一项对24个月以下因发热性呼吸道疾病住院的儿童进行的为期3年的前瞻性研究。使用多重聚合酶链反应（PCR）、酶联免疫测定和/或来自鼻咽样本的病毒培养物检测病毒病原体。通过PCR检测博德特氏菌感染。
结果
共纳入201例患者。187例（93%）患者检测到呼吸道病毒，其中52例（28%）为多病原体感染。检测到的最常见病毒是呼吸道合胞病毒和鼻病毒/肠道病毒。比较感染一种病原体的患者和多病原体感染的患者，疾病严重程度没有差异。
结论
因急性发热性呼吸道感染住院的幼儿中病毒共感染很常见，但似乎与疾病严重程度无关。
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