Department of Physiology, Ajou University School of Medicine, Suwon, Republic of Korea.
Phytother Res. 2013 Jun;27(6):829-34. doi: 10.1002/ptr.4809. Epub 2012 Aug 15.
The seeds of Zizyphus jujuba (SZJ), a famous oriental traditional medicine, have been reported to exhibit diverse activities in biological systems including the cardiovascular system. However, little information is available on its antiplatelet activity. This study was undertaken to investigate the antiplatelet effects of the ethanolic extract of SZJ (ESZJ) and of its principal components jujuboside A and B. In the in vitro platelet aggregation study, ESZJ exhibited significant and concentration-dependent inhibitory effects on collagen-, thrombin-, and AA-induced platelet aggregation. In addition, ESZJ-treated mice showed significantly the prolongation of bleeding times and the protection against thromboembolic attack. A comparison of the effects of jujuboside A and B on platelet aggregation revealed that only jujuboside B had potent inhibitory effects on collagen-, thrombin-, AA-, and ADP-induced aggregation. Jujuboside B also exhibited superior protection on thromboembolic model. Furthermore, jujuboside B had a significant inhibitory effect on collagen-induced thromboxane A2 production in rat platelets. This study describes the antiplatelet effects of ESZJ and of its active component jujuboside B, and its findings suggest that these agents be considered as components of preventive and therapeutic herbal drugs targeting cardiovascular diseases associated with platelet hyperaggregation.
酸枣仁（SZJ）是一种著名的东方传统药物，其种子已被报道在包括心血管系统在内的生物系统中具有多种活性。然而，关于其抗血小板活性的信息却很少。本研究旨在研究酸枣仁乙醇提取物（ESZJ）及其主要成分酸枣仁皂苷 A 和 B 的抗血小板作用。在体外血小板聚集研究中，ESZJ 对胶原、凝血酶和 AA 诱导的血小板聚集表现出显著的、浓度依赖性的抑制作用。此外，ESZJ 处理的小鼠表现出明显的出血时间延长和对血栓栓塞攻击的保护作用。比较酸枣仁皂苷 A 和 B 对血小板聚集的影响表明，只有酸枣仁皂苷 B 对胶原、凝血酶、AA 和 ADP 诱导的聚集具有强烈的抑制作用。酸枣仁皂苷 B 对血栓栓塞模型也表现出较好的保护作用。此外，酸枣仁皂苷 B 对胶原诱导的大鼠血小板血栓烷 A2 产生具有显著的抑制作用。本研究描述了 ESZJ 及其活性成分酸枣仁皂苷 B 的抗血小板作用，研究结果表明，这些药物可被视为针对与血小板过度聚集相关的心血管疾病的预防性和治疗性草药药物的组成部分。
