College of Pharmacy, Ajou University, Suwon 443-749, Republic of Korea.
Food Chem Toxicol. 2011 Dec;49(12):3018-24. doi: 10.1016/j.fct.2011.09.038. Epub 2011 Oct 7.
In this study, we investigated whether the methanolic extract of yuzu (yuzu ME) and its components hesperidin and naringin, have anti-platelet activities. Yuzu ME and hesperidin inhibited collagen-, arachidonic acid (AA)-, ADP- and thrombin-induced rat platelet aggregation in vitro and ex vivo. Naringin also inhibited platelet aggregation induced by collagen, AA, or thrombin, but not aggregation induced by ADP. The oral administration of yuzu ME or hesperidin prolonged mouse tail vein bleeding time in a dose-dependent manner in vivo. These results suggest that yuzu ME and hesperidin have anti-platelet activity, and that intake of yuzu, which includes various flavonoids such as hesperidin, may be beneficial for individuals at high risk of cardiovascular diseases.
在这项研究中，我们研究了柚子（yuzu）的甲醇提取物及其成分柚皮苷和柚皮苷元是否具有抗血小板活性。柚子 ME 和柚皮苷在体外和体内抑制了胶原、花生四烯酸（AA）、ADP 和凝血酶诱导的大鼠血小板聚集。柚皮苷元也抑制了胶原、AA 或凝血酶诱导的血小板聚集，但不抑制 ADP 诱导的聚集。柚子 ME 或柚皮苷的口服给药在体内以剂量依赖的方式延长了小鼠尾静脉出血时间。这些结果表明，柚子 ME 和柚皮苷具有抗血小板活性，摄入包含柚皮苷等多种类黄酮的柚子可能对心血管疾病高危人群有益。
