Radzi A M, Huan K S, Yahaya N, Shahera A, Kong N, Mohd Noah R
Biotechnology Unit, Institute for Medical Research, Kuala Lumpur.
Malays J Med Sci. 2001 Jul;8(2):32-9.
Age has been suggested to modify systemic lupus erythematosus expression. In this study we have attempted to study 13 patients with late onset (40 years and above) and 90 with early onset disease (below 40 years) to determine whether age-related differences in disease expression exist and whether the genetic make-up influences the age of disease onset. We found that patients with late onset disease initially presented with pericarditis (31% vs 3%, P<0.005) and a lower incidence of malar rash (31% vs 57%, p<0.05). During the disease course, there was a lower incidence of mucocutaneous symptoms especially malar rash (p<0.005) and psychosis (p<0.05) in the late onset group. Serological parameters were similar in both groups. There was a prevalence of HLA-DQA10103 in Chinese patients with late onset disease (pcorr=0.004). These findings suggest that a subgroup of late onset patients may experience milder disease and that the risk conferred by the HLA-DQA10103 may be significant among these patients.
有研究表明年龄会影响系统性红斑狼疮的表现。在本研究中，我们试图对13例晚发型（40岁及以上）患者和90例早发型（40岁以下）患者进行研究，以确定疾病表现是否存在与年龄相关的差异，以及基因构成是否会影响疾病的发病年龄。我们发现，晚发型疾病患者最初表现为心包炎（31% 对3%，P<0.005），且颊部皮疹的发生率较低（31% 对57%，p<0.05）。在疾病过程中，晚发型组的黏膜皮肤症状尤其是颊部皮疹（p<0.005）和精神病（p<0.05）的发生率较低。两组的血清学参数相似。在中国晚发型疾病患者中存在HLA-DQA10103的流行趋势（校正p值=0.004）。这些发现表明，晚发型患者亚组可能经历较轻的疾病，并且HLA-DQA10103在这些患者中所带来的风险可能很大。
