Shaikh S K, Wang F
Department of Nephrology, Hospital Kuala Lumpur.
Med J Malaysia. 1995 Mar;50(1):25-31.
Between January 1976 and December 1992, 17 patients on follow-up at Systemic Erythematosus (SLE) Clinic in the University Hospital, Kuala Lumpur had onset of the disease after the age of 50 years. This constituted about 4% of our total SLE patients. They formed a distinct subgroup of the lupus population with an insidious onset and have a benign course compared to the younger SLE patients. Arthritis and skin rashes were the commonest initial manifestations. Renal and central nervous system manifestations were uncommon but pulmonary involvement was frequent compared to young SLE patients. The prevalence of positive autoantibodies and hypocomplementaemia were lower. Disease activity showed no correlation with erythrocyte sendimentation rate, autoantibodies or complement levels. Overall prognosis in these late-onset patients was favourable with a good response to steroids and less frequent relapses.
1976年1月至1992年12月期间，吉隆坡大学医院系统性红斑狼疮（SLE）门诊接受随访的患者中有17例在50岁之后发病。这约占我们SLE患者总数的4%。他们构成了狼疮人群中一个独特的亚组，起病隐匿，与年轻的SLE患者相比病程较为良性。关节炎和皮疹是最常见的初始表现。肾脏和中枢神经系统表现不常见，但与年轻SLE患者相比肺部受累较为频繁。自身抗体阳性和补体低下的发生率较低。疾病活动度与红细胞沉降率、自身抗体或补体水平无关。这些晚发型患者的总体预后良好，对类固醇反应良好且复发频率较低。
