Université de Montréal, Montréal, QC, Canada.
Eur J Psychotraumatol. 2012;3. doi: 10.3402/ejpt.v3i0.15470. Epub 2012 Feb 14.
In two recent studies conducted by our group, a treatment combining propranolol with a brief reactivation session subsequently reduced posttraumatic stress disorder (PTSD) symptom severity and diagnosis, as well as reducing psychophysiological responses during trauma-related script-driven imagery. One likely explanation for those results is that memory reconsolidation was blocked by propranolol.
We explored the influence of various predictors on treatment outcome (i.e., PTSD severity), and whether the treated individuals improved in other important domains of functioning associated with PTSD.
Thirty-three patients with longstanding PTSD participated in a 6-week open-label trial consisting of actively recalling one's trauma under the influence of propranolol, once a week.
Treated patients reported a better quality of life, less comorbid depressive symptoms, less negative emotions in their daily life and during trauma recollections. Women were also found to improve more than men. Type of trauma (childhood vs. adulthood), time elapsed since trauma, borderline personality traits, depressive symptoms severity, Axis I comorbidity, and age did not influence treatment outcome.
These results must await publication of a randomized-controlled trial to further delineate effectiveness with this novel treatment approach.
在我们小组最近进行的两项研究中，一种将普萘洛尔与短暂的再激活疗程相结合的治疗方法，降低了创伤后应激障碍（PTSD）的症状严重程度和诊断率，同时降低了创伤相关脚本驱动意象期间的心理生理反应。这些结果的一个可能解释是，普萘洛尔阻断了记忆再巩固。
我们探讨了各种预测因素对治疗结果（即 PTSD 严重程度）的影响，以及接受治疗的个体是否在与 PTSD 相关的其他重要功能领域得到改善。
33 名患有长期 PTSD 的患者参加了一项为期 6 周的开放性试验，该试验包括在普萘洛尔的影响下每周主动回忆一次创伤。
接受治疗的患者报告生活质量更好，共病抑郁症状更少，日常生活和创伤回忆中的负面情绪更少。女性的改善也比男性更明显。创伤类型（儿童期与成年期）、创伤发生时间、边缘型人格特质、抑郁症状严重程度、轴 I 共病和年龄均不影响治疗结果。
这些结果必须等待随机对照试验的发表，以进一步明确这种新治疗方法的有效性。
