National Cheng-Kung University, Department of Photonics, Tainan 701, Taiwan.
J Biomed Opt. 2012 Jul;17(7):077005. doi: 10.1117/1.JBO.17.7.077005.
Collagen is a rich component in skin that provides skin structure integrity; however, its contribution to the absorption and scattering properties of various types of skin has not been extensively studied. We considered the contribution of the collagen to the absorption spectrum of in vivo normal skin and keloids of 12 subjects derived from our diffuse reflectance spectroscopy (DRS) system in the wavelength range from 550 to 860 nm. It was found that the collagen concentration, the hemoglobin oxygen saturation, and the reduced scattering coefficient of keloids were remarkably different from that of normal skin. Our results suggest that our DRS system could assist clinicians in understanding the functional and structural condition of keloid scars. In the future, we will evaluate the accuracy of our system in the keloid diagnosis and investigate the applicability of our system for other skin-collagen-related studies.
胶原是皮肤中丰富的成分，为皮肤结构的完整性提供支持；然而，其对各种类型皮肤的吸收和散射特性的贡献尚未得到广泛研究。我们考虑了胶原对我们的漫反射光谱（DRS）系统在 550 到 860nm 波长范围内获得的 12 个对象的正常皮肤和瘢痕疙瘩的吸收光谱的贡献。发现瘢痕疙瘩的胶原浓度、血红蛋白氧饱和度和比散射系数与正常皮肤有显著差异。我们的结果表明，我们的 DRS 系统可以帮助临床医生了解瘢痕疙瘩的功能和结构状况。在未来，我们将评估我们系统在瘢痕疙瘩诊断中的准确性，并研究我们系统在其他与皮肤胶原相关的研究中的适用性。
