Zonios G, Bykowski J, Kollias N
Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard University Medical School, Boston, Massachusetts, USA.
J Invest Dermatol. 2001 Dec;117(6):1452-7. doi: 10.1046/j.0022-202x.2001.01577.x.
Noninvasive and real-time analysis of skin properties is useful in a wide variety of applications. In particular, the quantitative assessment of skin in terms of hemoglobin and melanin content, as well as in terms of its light scattering properties, is a challenging problem in dermatology. We present here a technique for examining human skin, based on the in vivo measurement of diffuse reflectance spectra in the visible and near-infrared ranges of the electromagnetic spectrum. Spectra were measured by means of a fiber optic probe, and they were analyzed using an analytical model of light diffusion in the skin. The results of the analysis indicate that it is possible to obtain quantitative information about hemoglobin and melanin content, as well as basic information regarding the scattering properties of the skin.
皮肤特性的无创实时分析在众多应用中都很有用。特别是,从血红蛋白和黑色素含量以及光散射特性方面对皮肤进行定量评估,是皮肤病学中的一个具有挑战性的问题。我们在此介绍一种基于在电磁光谱的可见光和近红外范围内对漫反射光谱进行体内测量来检测人体皮肤的技术。光谱通过光纤探头进行测量,并使用皮肤中光扩散的分析模型进行分析。分析结果表明,有可能获得关于血红蛋白和黑色素含量的定量信息,以及有关皮肤散射特性的基本信息。