Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
BMC Public Health. 2012 Aug 15;12:659. doi: 10.1186/1471-2458-12-659.
Early life body size and circulating levels of IGF-1 and IGFBP-3 have been linked to increased risks of breast and other cancers, but it is unclear whether these exposures act through a common mechanism. Previous studies have examined the role of IGF-1 and IGFBP-3 genetic variation in relation to adult height and body size, but few studies have examined associations with birthweight and childhood size.
We examined whether htSNPs in IGF-1 and the IGFBP-1/IGFBP-3 gene region are associated with the self-reported outcomes of birthweight, body fatness at ages 5 and 10, and body mass index (BMI) at age 18 among healthy women from the Nurses' Health Study (NHS) and NHSII. We used ordinal logistic regression to model odds ratios (ORs) and 95% confidence intervals (CI) of a one category increase for birthweight and somatotypes at ages 5 and 10. We used linear regression to model associations with BMI at age 18.
Among 4567 healthy women in NHS and NHSII, we observed no association between common IGF-1 or IGFBP-1/IGFBP-3 SNPs and birthweight, body fatness at ages 5 and 10, or BMI at age 18.
Common IGF-1 and IGFBP-1/IGFBP-3 SNPs are not associated with body size in early life.
婴儿期的身体大小和循环中的 IGF-1 和 IGFBP-3 水平与增加乳腺癌和其他癌症的风险有关，但尚不清楚这些暴露是否通过共同的机制起作用。先前的研究已经研究了 IGF-1 和 IGFBP-1/IGFBP-3 基因区域中的遗传变异与成人身高和体型的关系，但很少有研究检查与出生体重和儿童期体型的关联。
我们研究了 IGF-1 中的 htSNPs 以及 IGFBP-1/IGFBP-3 基因区域中的 SNPs 是否与健康女性的出生体重、5 岁和 10 岁时的体脂肪率以及 18 岁时的体重指数 (BMI) 有关。我们使用有序逻辑回归模型来对出生体重和 5 岁和 10 岁时的体型进行单一类别增加的比值比 (OR) 和 95%置信区间 (CI)。我们使用线性回归模型来关联 BMI 与 18 岁时的 BMI。
在 NHS 和 NHSII 中的 4567 名健康女性中，我们没有观察到常见的 IGF-1 或 IGFBP-1/IGFBP-3 SNP 与出生体重、5 岁和 10 岁时的体脂肪率或 18 岁时的 BMI 之间存在关联。
常见的 IGF-1 和 IGFBP-1/IGFBP-3 SNP 与婴儿期的体型大小无关。
