Transfusion Department, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Laboratory Medicine, the Second Affiliated Hospital of Chongqing Medical University, No.74 Linjiang Road, Chonqing, 400010, Yuzhong District, China.
BMC Med Genet. 2019 Jan 17;20(1):17. doi: 10.1186/s12881-019-0749-3.
Many epidemiological studies have suggested that insulin-like growth factor1 (IGF1) gene single-nucleotide polymorphisms (SNPs) may be associated with cancer risk. Among several commonly studied polymorphisms in IGF1 gene, rs2195239 and rs2162679 attracted many attentions. So we perform a meta-analysis to determine potential associations between IGF1 rs2195239 and rs2162679 polymorphisms and cancer risk.
We retrieved relevant articles from the PubMed, Embase, and Web of Science databases up to April 30, 2018. Ultimately, thirteen studies were included in the present meta-analysis, which involved 12,515 cases and 19,651 controls. The odd ratios (ORs) and their 95% confidence intervals (CIs) were pooled to estimate the strength of the associations.
rs2195239 reduces the overall cancer risk in homozygote model, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models. No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
IGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.
许多流行病学研究表明，胰岛素样生长因子 1（IGF1）基因单核苷酸多态性（SNP）可能与癌症风险相关。在 IGF1 基因中研究较多的几个多态性中，rs2195239 和 rs2162679 引起了广泛关注。因此，我们进行了一项荟萃分析，以确定 IGF1 rs2195239 和 rs2162679 多态性与癌症风险之间的潜在关联。
我们从 PubMed、Embase 和 Web of Science 数据库中检索了截至 2018 年 4 月 30 日的相关文章。最终，有 13 项研究纳入了本荟萃分析，涉及 12515 例病例和 19651 例对照。汇总了比值比（OR）及其 95%置信区间（CI），以评估关联的强度。
rs2195239 在同型模型中降低了总体癌症风险，并且在等位基因、同型和隐性模型中降低了亚洲人群的癌症风险。rs2195239 与乳腺癌或胰腺癌风险之间没有显著关系。rs2162679 在等位基因、同型、显性和隐性模型中降低了总体癌症风险，并且在等位基因、同型和隐性模型中降低了亚洲人群的癌症风险。
根据目前的研究，IGF1 rs2195239 和 rs2162679 与总体癌症风险相关。
