富兰克林·H·爱泼斯坦讲座。牵绳的两端——与携带不良基因的好狗相关的人类联系。
Franklin H. Epstein Lecture. Both ends of the leash--the human links to good dogs with bad genes.
机构信息
National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
N Engl J Med. 2012 Aug 16;367(7):636-46. doi: 10.1056/NEJMra1204453.
Abstract
For nearly 350 years, veterinary medicine and human medicine have been separate entities, with one geared toward the diagnosis and treatment in animals and the other toward parallel goals in the owners. However, that model no longer fits, since research on diseases of humans and companion animals has coalesced. The catalyst for this union has been the completion of the human genome sequence, coupled with draft sequence assemblies of genomes for companion animals. Here, we summarize the critical events in canine genetics and genomics that have led to this development, review major applications in canine health that will be of interest to human caregivers, and discuss expectations for the future.
摘要
近 350 年来，兽医和人医一直是两个独立的实体，一个专注于动物的诊断和治疗，另一个则专注于主人的类似目标。然而，这种模式已经不再适用，因为人类和伴侣动物疾病的研究已经融合在一起。这种结合的催化剂是人类基因组序列的完成，加上伴侣动物基因组草图序列的组装。在这里，我们总结了导致这一发展的犬遗传学和基因组学的关键事件，回顾了对人类护理人员有兴趣的犬健康的主要应用，并讨论了未来的预期。
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