Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, USA.
Org Lett. 2012 Sep 7;14(17):4482-5. doi: 10.1021/ol301984b. Epub 2012 Aug 15.
A new copper(II) 2-ethylhexanoate-promoted addition of an alcohol and an amine across an alkene (oxyamination) is reported. The alcohol addition is intramolecular, while coupling with the amine occurs intermolecularly. Several 2-aminomethyl morpholines were synthesized in good to excellent yields and diastereoselectivities.
报道了一种新的铜(II) 2-乙基己酸酯促进的醇和胺与烯烃(肟化)加成反应。醇的加成是分子内的,而与胺的偶联是分子间的。几种 2-氨甲基吗啉以良好到优异的产率和非对映选择性合成。