铜催化的 1,1-二取代-4-亚甲基-1,6-己二醇和相关烯丙醇构建桥环双环缩酮的对映选择性合成。
Copper-catalyzed enantioselective synthesis of bridged bicyclic ketals from 1,1-disubstituted-4-methylene-1,6-hexanediols and related alkenols.
机构信息
Chemistry Department, Natural Science Complex, State University of New York at Buffalo, Buffalo, New York 14260, USA.
出版信息
Chem Commun (Camb). 2021 Jan 5;57(1):105-108. doi: 10.1039/d0cc06404a.
Abstract
Bridged bicyclic ketals display a range of bioactivities. Their catalytic enantioselective synthesis from acyclic 1,1-disubstituted alkene diols is disclosed. This reaction combines asymmetric catalysis with a distal radical migration. Alkynes and arenes undergo the group transfer.
摘要
桥环双环缩酮显示出多种生物活性。本文公开了它们从非环 1,1-二取代烯丙醇二醇催化对映选择性合成的方法。该反应将不对称催化与远程自由基迁移结合在一起。炔烃和芳基化合物进行基团转移。
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