Mello L E, Masur J, Formigoni M L, Kireeff W, Cavalheiro E A
Disciplina de Neurologia Experimental, Escola Paulista de Medicina, São Paulo, Brazil.
Epilepsy Res. 1990 Nov;7(2):95-104. doi: 10.1016/0920-1211(90)90094-c.
The effects of chronic ethanol administration were studied in rats receiving amygdaloid kindling. Daily ethanol administration 10 min prior to kindling stimulation delayed acquisition of kindling without affecting the electrical afterdischarge. For the lowest tested dose of ethanol (0.5 g/kg), this delay was restricted to kindling stages 1 and 2. For the higher doses of ethanol (1.0 and 1.5 g/kg) this delay became more severe and stages 3 and 4 were blocked. Ethanol produced a clear dose-related anticonvulsant effect upon kindled seizures. After repeated exposure to kindling stimulation and ethanol this anticonvulsant effect vanished. After a 15-day interval without stimulation or ethanol application kindled animals were insensitive to ethanol's anticonvulsant effect. In conclusion, it is suggested that the anticonvulsant effects of low ethanol doses are restricted to kindling stages 1 and 2 and that anticonvulsant effects of high ethanol doses are limited by tolerance and by the level of consolidation of the kindled seizure. Finally, we suggest that the anticonvulsant properties of ethanol are not due to its general depressant effect but to some rather specific action.
在接受杏仁核点燃的大鼠中研究了长期给予乙醇的影响。在点燃刺激前10分钟每日给予乙醇，延迟了点燃的获得，但不影响电后放电。对于所测试的最低乙醇剂量（0.5克/千克），这种延迟仅限于点燃的第1和第2阶段。对于较高剂量的乙醇（1.0和1.5克/千克），这种延迟变得更严重，第3和第4阶段被阻断。乙醇对点燃性癫痫发作产生明显的剂量相关抗惊厥作用。在反复暴露于点燃刺激和乙醇后，这种抗惊厥作用消失。在间隔15天不给予刺激或乙醇后，点燃的动物对乙醇的抗惊厥作用不敏感。总之，提示低剂量乙醇的抗惊厥作用仅限于点燃的第1和第2阶段，高剂量乙醇的抗惊厥作用受耐受性和点燃性癫痫发作巩固水平的限制。最后，我们认为乙醇的抗惊厥特性不是由于其一般的抑制作用，而是由于某种相当特殊的作用。
