Kim C K, Dalal S, Pinel J P, Weinberg J
Department of Anatomy, University of British Columbia, Vancouver, Canada.
Alcohol Clin Exp Res. 1994 Dec;18(6):1506-14. doi: 10.1111/j.1530-0277.1994.tb01458.x.
The present experiments assessed the effects of prenatal ethanol exposure on the susceptibility to convulsions and on the anticonvulsant effect of ethanol using the electrical kindling model of epilepsy in rats. Adult male Sprague-Dawley rats from prenatal ethanol (E), pair-fed (PF), and ad libitum-fed control (C) treatment groups were tested following the implantation of a stimulation electrode in the left amygdala complex. The same rats were tested in four consecutive experiments. Both E and PF rats showed a slightly slower rate of kindling than C rats, as measured by convulsion class but not as measured by forelimb clonus duration (experiment 1). However, the groups did not differ significantly in the electrical stimulation threshold for kindled convulsions (experiment 2). Furthermore, prenatal ethanol exposure had no significant effect on the dose-response curve for ethanol's (0, 0.9, 1.1, 1.3, and 1.5 g/kg, ip) anticonvulsant effect (experiment 3), or on the rate of tolerance development to ethanol's (1.5 g/kg, ip) anticonvulsant effect (experiment 4) on kindled convulsions. Thus, prenatal exposure to ethanol does not appear to have long-term effects on the susceptibility to convulsions or on the anticonvulsant effect of ethanol in adult male rats in the kindling model as used in the present experiments.
本实验使用大鼠癫痫电点燃模型，评估产前乙醇暴露对惊厥易感性以及乙醇抗惊厥作用的影响。将成年雄性斯普拉格-道利大鼠分为产前乙醇（E）组、配对喂养（PF）组和自由进食对照组（C），在左侧杏仁核复合体植入刺激电极后对这些组的大鼠进行测试。同一只大鼠连续进行四项实验。通过惊厥分级测量发现，E组和PF组大鼠的点燃速度均略慢于C组大鼠，但以前肢阵挛持续时间测量时并非如此（实验1）。然而，在点燃惊厥的电刺激阈值方面，各组之间没有显著差异（实验2）。此外，产前乙醇暴露对乙醇（0、0.9、1.1、1.3和1.5 g/kg，腹腔注射）抗惊厥作用的剂量反应曲线没有显著影响（实验3），对乙醇（1.5 g/kg，腹腔注射）抗惊厥作用在点燃惊厥上的耐受性发展速度也没有显著影响（实验4）。因此，在本实验所使用的点燃模型中，产前乙醇暴露似乎对成年雄性大鼠的惊厥易感性或乙醇的抗惊厥作用没有长期影响。
