松果体切除对皮层点燃大鼠的影响。

Effect of pinealectomy on cortically kindled rats.

作者信息

Ninchoji T, Uemura K, Shimoyama I

机构信息

Department of Neurosurgery, Hamamatsu University School of Medicine, Shizuoka, Japan.

出版信息

Epilepsy Res. 1990 Dec;7(3):240-4. doi: 10.1016/0920-1211(90)90021-m.

DOI:10.1016/0920-1211(90)90021-m

PMID:2289483

Abstract

Cortical kindling in pinealectomized rats was studied to observe the effect of pinealectomy on local afterdischarge thresholds and seizure development. Although the local afterdischarge thresholds were not affected by pinealectomy, the kindling process itself was hastened. These results suggest that the anticonvulsive function of the pineal body is due not to a decrease in local afterdischarge thresholds, but to retardation of secondary generalization.

摘要

研究了松果体切除大鼠的皮质点燃效应，以观察松果体切除对局部后放电阈值和癫痫发作发展的影响。虽然局部后放电阈值不受松果体切除的影响，但点燃过程本身却加快了。这些结果表明，松果体的抗惊厥功能并非由于局部后放电阈值的降低，而是由于继发性泛化的延迟。