Department of Biochemistry, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Prion. 2012 Nov-Dec;6(5):417-9. doi: 10.4161/pri.21826. Epub 2012 Aug 16.
Mammalian prions with significant levels of specific infectivity can be formed in vitro from mixtures of prion protein (PrP) and cofactor molecules, but not from PrP alone. We recently isolated and identified the essential membrane phospholipid phosphatidylethanolamine (PE) as an endogenous cofactor for prion propagation in vitro. ( 1) In this article, we discuss the potential role of PE and other essential cofactor molecules as a molecular link between the processes of prion formation and prion-induced neurodegeneration.
哺乳动物朊病毒在具有显著感染特异性的水平下，可以在朊病毒蛋白（PrP）和辅助因子分子的混合物中体外形成，但不能仅由 PrP 形成。我们最近分离并鉴定了必需的膜磷脂磷脂酰乙醇胺（PE）作为朊病毒在体外增殖的内源性辅助因子。(1) 在本文中，我们讨论了 PE 和其他必需辅助因子分子作为朊病毒形成和朊病毒诱导的神经退行性变过程之间的分子联系的潜在作用。
