Departments of Pathology, University of Virginia Medical Center, Charlottesville, VA, USA.
Am J Surg Pathol. 2012 Sep;36(9):1410-4. doi: 10.1097/PAS.0b013e31826277a9.
We describe a primary ovarian neoplasm, occurring in a 15-year-old female patient, with morphologic, immunohistochemical, and molecular genetic features identical to those of the very rare tumors of the kidney previously described as "melanotic Xp11 translocation renal cancer." This represents, to the best of our knowledge, the first report of a melanotic Xp11 translocation-associated neoplasm arising outside of the kidney. We discuss the relationship of these rare tumors to neoplasms showing perivascular epithelioid cell differentiation, in particular those showing TFE3 rearrangements.
我们描述了一例发生于 15 岁女性患者的原发性卵巢肿瘤，其形态学、免疫组织化学和分子遗传学特征与先前描述的极为罕见的“黑色素 Xp11 易位性肾癌”的肿瘤完全一致。据我们所知，这代表了首例发生于肾脏以外的黑色素 Xp11 易位相关性肿瘤。我们讨论了这些罕见肿瘤与具有血管周上皮样细胞分化的肿瘤，特别是那些具有 TFE3 重排的肿瘤之间的关系。
