Rao Qiu, Xia Qiu-Yuan, Cheng Liang, Zhou Xiao-Jun
1 Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China ; 2 Department of Pathology and Laboratory, Indiana University School of Medicine, Indianapolis, IN, USA.
Chin J Cancer Res. 2016 Feb;28(1):29-49. doi: 10.3978/j.issn.1000-9604.2016.01.03.
Renal cell carcinoma (RCC) compromises multiple types and has been emerging dramatically over the recent several decades. Advances and consensus have been achieved targeting common RCCs, such as clear cell carcinoma, papillary RCC and chromophobe RCC. Nevertheless, little is known on the characteristics of several newly-identified RCCs, including clear cell (tubulo) papillary RCC, Xp11 translocation RCC, t(6;11) RCC, succinate dehydrogenase (SDH)-deficient RCC, acquired cystic disease-associated RCC, hereditary leiomyomatosis RCC syndrome-associated RCC, ALK translocation RCC, thyroid-like follicular RCC, tubulocystic RCC and hybrid oncocytic/chromophobe tumors (HOCT). In current review, we will collect available literature of these newly-described RCCs, analyze their clinical pathologic characteristics, discuss their morphologic and immunohistologic features, and finally summarize their molecular and genetic evidences. We expect this review would be beneficial for the understanding of RCCs, and eventually promote clinical management strategies.
肾细胞癌（RCC）有多种类型，在最近几十年中显著增多。针对常见的肾细胞癌，如透明细胞癌、乳头状肾细胞癌和嫌色性肾细胞癌，已经取得了进展并达成了共识。然而，对于几种新发现的肾细胞癌的特征，包括透明细胞（小管）乳头状肾细胞癌、Xp11易位性肾细胞癌、t(6;11)肾细胞癌、琥珀酸脱氢酶（SDH）缺陷型肾细胞癌、获得性囊性疾病相关性肾细胞癌、遗传性平滑肌瘤病肾细胞癌综合征相关性肾细胞癌、ALK易位性肾细胞癌、甲状腺样滤泡性肾细胞癌、肾小管囊性肾细胞癌和混合性嗜酸性细胞/嫌色性肿瘤（HOCT），人们了解甚少。在本综述中，我们将收集这些新描述的肾细胞癌的现有文献，分析它们的临床病理特征，讨论它们的形态学和免疫组织化学特征，最后总结它们的分子和遗传学证据。我们期望本综述将有助于对肾细胞癌的理解，并最终促进临床管理策略的发展。
